******* Workshop Announcement ****************
Workshop on Modeling and Analysis of Biological Regulatory Networks
American Control Conference
Minneapolis, Minnesota USA
June 13, 2006
Francis J. Doyle III (University of California, Santa Barbara) and
Michael A. Henson (University of Massachusetts, Amherst)
Systems biology has emerged as a prominent new field that provides a
much needed interface between the life sciences and quantitative
disciplines including engineering and mathematics. The novelty of
systems biology lies in the emphasis on analyzing complexity in
networked biological systems using integrative rather than reductionist
approaches. The aim of this workshop is to provide an introduction to a
particular domain of systems biology to which classically trained
control engineers have made substantial contributions: the modeling and
analysis of cellular regulatory networks. The necessary biological
background will be introduced by reviewing basic concepts of genetic and
metabolic regulation as well as cellular signaling. Examples ranging
from the generation of circadian rhythms to the regulation of energy
metabolism will be used to illustrate modeling and analysis methods.
Tentative Schedule
8:30-8:45 - Course overview (Doyle)
8:45-9:30 - Review of genetic regulation (Doyle)
9:30-10:15 - Modeling of gene regulatory and signal transduction
networks (Doyle)
10:15-10:45 - Break
10:45-11:15 - Case study: lambda phage (Doyle)
11:15-12:00 - Case study: circadian rhythm (Doyle)
12:00-12:30 - Case study: cell cycle (Henson)
12:30-1:30 - Lunch
1:30-2:15 - Review of metabolic regulation (Henson)
2:15-3:00 - Modeling of metabolic networks (Henson)
3:00-3:30 - Break
3:30-4:00 - Case study: energy metabolism (Henson)
4:00-4:45 - Metabolic flux and control analysis (Henson)
4:45-5:30 - Case study: whole cell metabolism (Henson)
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